Endocrine Abstracts

Background: Studies of memory function in patients treated for pituitary adenoma demonstrate deficits in immediate memory (IM) regardless of whether surgery or radiotherapy was received. We have previously shown variability in IM between patients who received the same treatment. The present study was designed to identify changes in the neurological pathways associated with memory function in patients treated for non-functioning pituitary adenoma (NFA) using functional magnetic...

Background: Surgery, sometimes supported by adjunctive radiotherapy (RT), is the treatment of choice for patients with non-functioning pituitary adenoma (NFA). Previous studies have shown that patients treated with pituitary RT have doubling of mortality ratio due to cerebrovascular disease (CVD) but the reason for this excess is unclear. Transcranial Doppler (TCD) can be used to measure blood velocity in the middle cerebral arteries (MCAs) within the circle of Willis and also...

Background: Surgery, sometimes supported by adjunctive radiotherapy (RT) are the treatments of choice for patients with non-functioning pituitary adenomas (NFA). Previous studies have implicated these treatments in deficits of cognitive function, particularly memory and executive functioning, although this research has often been confounded by the inclusion of patients with hormone producing tumours. The aim of this study was to determine the impact of RT on psychometric funct...

Background: After adrenalectomy (ADX) for primary aldosteronism (PA), approximately 30% of patients achieve clinical success (normalisation of home BP); many additional patients report feeling subjectively better. We used the non-randomised MATCH study1 to further assess quality of life (QoL) changes in participants.Objective: Assess QoL using the 36-item Short Form Health Survey (SF-36) after surgical treatment of unilateral PA and medical treatment of ...